Van Hoek’s lab

OSCAR-Mentor-Awardees

OSCAR Award Recipients

Award

Dr. van Hoek receives 2013 OSCAR Mentoring Excellence Award.  http://oscar.gmu.edu/fac-staff/oscar-mentor-award.cfm

Paper

A new paper on the role of the human antimicrobial peptide LL-37 for wound healing from the van Hoek Lab.

Allen J. Duplantier and Monique L. van Hoek, “The human cathelicidin antimicrobial peptide LL-37 as a potential treatment for polymicrobial infected wounds”  Frontiers in Immunology (Molecular Innate Immunity), July 2013.

http://www.frontiersin.org/Molecular_Innate_Immunity/10.3389/fimmu.2013.00143/abstract

JSTO-In the News (CBS Input – December 2012) “DTRA Funded Effort Studies Anti-infective Properties of Reptile Serum

Seven months ago, DTRA initiated a research effort to take advantage of the anti-infective properties of reptile serum. The concept is to identify and use constitutive parts of serum that enables animals to fight infection, notably cationic antimicrobial peptides. These peptides will be isolated using a novel, nanoparticle-based approach.

The foundation for this DTRA-funded work is research performed at George Mason University (GMU) in the laboratories of Dr. Monique van Hoek (National Center for Biodefense and Infectious Diseases) and Dr. Barney Bishop (Department of Chemistry) that demonstrated anti-microbial and anti-biofilm properties of these CAMPs. Recently, their published work has been recognized by the respective journals as being among the highest viewed articles.  For example, their paper in Frontiers in Microbiology has received 1391 views [1]. The companion paper in BMC Microbiology was “Highly Accessed” with 5647 views so far [2], and a second companion paper in BBRC received a favorable score in a Faculty of 1000 review [3,4]. All of the researchers and students involved are very excited to be working on this project. The principal investigator on the project HDTRA1-12-C-0039 “Translational Peptides for Personal Protection” is Dr. Joel Schnur. (POC Al Graziano, 767-3360)”

1. Dean, S. N., Bishop, B. M., & Van Hoek, M. L. (2011). Susceptibility of Pseudomonas aeruginosa biofilm to alpha-helical peptides: D-enantiomer of LL-37. Frontiers in Microbiology, 2.

2. Dean, S. N., Bishop, B. M., & van Hoek, M. L. (2011). Natural and synthetic cathelicidin peptides with anti-microbial and anti-biofilm activity against Staphylococcus aureus. BMC Microbiology, 11(1), 114.

3. Amer, L. S., Bishop, B. M., & van Hoek, M. L. (2010). Antimicrobial and antibiofilm activity of cathelicidins and short, synthetic peptides against Francisella. Biochemical and Biophysical Research Communications, 396(2), 246-251.

4. http://f1000.com/prime/6167956

http://ncbid.cos.gmu.edu/2013/01/09/1273/

Novel approach to antimicrobial peptide research featured in TedxGeorgeMasonU talk by Dr. van Hoek.

TEDxGeorgeMasonU talk: “Healed by a Crocodile: the Search for New Antibiotics”. April 6th 2013.  TEDxGeorgeMasonU talk: “Healed by a Crocodile: the Search for New Antibiotics”. April 6th 2013

Expert Commentary

http://www.rsc.org/chemistryworld/2014/03/molecular-drill-bits-amp-peptides-attack-tuberculosis-bacteria

Chemistry World: Could wasp venom peptide keep catheters sterile? 14 August 2013:  Expert Commentary: Chemistry World: Could wasp venom peptide keep catheters sterile? 14 August 2013

Paper

van Hoek Lab paper on Antimicrobial peptides and Francisella featured in Faculty of 1000:  Amer, L. S., Bishop, B. M., & van Hoek, M. L. (2010). Antimicrobial and antibiofilm activity of cathelicidins and short, synthetic peptides against Francisella. Biochemical and Biophysical Research Communications, 396(2), 246-251.

4. http://f1000.com/prime/6167956

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