Charles Bailey Ph.D., Distinguished Professor of Biology, Executive Director

Biosketch:

Prior to joining George Mason, Dr. Bailey served in the US Army for 25 years where he conducted research on arthropod borne viral diseases in the US, Southeast Asia and Africa. Some of Bailey’s duties included: Research scientist at the Southeast Asia Treaty Organization (SEATO) Medical Research Laboratory in Bangkok Thailand, Chief of Entomology at the Walter Reed Army Institute of Research in Washington DC. In July of 1980, Dr. Bailey was transferred to the US Army Medical Research Institute of Infectious Diseases (USAMRIID) at Fort Detrick, Frederick Maryland. The mission of this laboratory was to develop diagnostics, therapeutics and vaccines against biological agents that could be used as weapons against US Military personnel. Dr. Bailey served at this laboratory for the next 13 years in the following capacities: Chief of Arboviral Entomology, Deputy Commander for Research, Deputy Commander and Commander. Dr. Bailey retired from the Army as a Colonel in August of 1993 and holds a doctorate from Oklahoma State University. Prior to joining George Mason, Bailey served as a senior analyst with the Defense Intelligence Agency and as an analyst for the Battelle Memorial Institute.

Research Interests:

After joining George Mason University, Bailey applied for a construction grant from the National Institute of Allergy and Infectious Diseases. This application resulted in an award of $27.7 million to build the Biosafety Level 3 Biomedical Research Laboratory, which is now the home of Masons NCBDID on the Prince William Campus.

Publications:

Chung, M.C., Popova, T.G., Jorgensen S.C., Dong L., Candhoke V., Bailey C.L., Popov S.G. Degradation of circulating von Willebrand factor and its regulator ADAMTS13 implicates secreted Bacillus anthracis metalloproteases in anthrax consumptive coagulopathy. J Biol Chem. 2008 April 11; 283(15):9531-9542.

Chung M.C., Jorgensen S.C., Popova T.G., Bailey C.L., Popov S.G. Neutrophil elastase and syndecan shedding contribute to antithrombin depletion in murine anthrax. FEMS Immunol Med Microbiol. 2008 Dec; 54(3): 309-318.

Bradburne C., Chung M.C., Zong Q., Schlauch K, Liu D, Popova T, Popova A, Bailey C, Soppet D, Popov S. Transciptional and apoptotic responses of THP-1 cells to challenge with toxigenic, and non-toxigenic Bacillus anthracis. BMC Immunol. 2008 Nov 13; 9:67.

M.C Chung, S.C. Jorgensen, T.G. Popova, J.H. Tonry, C.L. Bailey, S.G. Popov. Activation of plasminogen activator inhibitor implicates protease InhA in the acute-phase response to Bacillus anthracis infection. J Med Microbiol. 2009; 58 (6): 737-744.

Aarthi Narayanan, Weidong Zhou, Mark Ross, Jane Tang, Lance Liotta, Emanuel Petricoin, Fatah Kashanchi, Charles Bailey, Serguei Popov. Discovery of Infectious Disease Biomarkers in Murine Anthrax Model Using Mass Spectrometry of the Low-Molecular-Mass Serum Proteome. 2009. J Proteomics Bioinform 2(9):408-415

Taissia Popova, Virginia Espina, Charles Bailey, Lance Liotta, Emanuel Petricoin, and Serguei Popov. Anthrax infection inhibits the AKT signaling involved in the E-cadherin-mediated adhesion of lung epithelial cells. 2009. FEMS Immunol Medical Microbiol 56(2):129-142.

Popova, T. G., Millis, B., Chung, M.-C., Bailey, C. and Popov, S. G. (2011), Anthrolysin O and fermentation products meiate the toxicity of Bacillus anthracis to lung epithelial cells under microaerobic conditions. FEMS Immunology & Medical Microbiology, 61: 15–27.

Narayanan A, Popova T, Turell T, Kidd J, Chertow J, Popov S, Bailey C, Kashanchi F, Kehn-Hall K.  2011. Alteration in superoxide dismutase 1 causes oxidative stress and p38 MAPK activation following RVFV infection.  PLoS ONE. 6(5):e20354.

Narayanan A, Bailey C, Kashanchi F, Kehn-Hall K. 2011. Developments in antivirals against influenza, smallpox and hemorrhagic fever viruses. Expert Opin Investig Drugs. 20(2):239-54.

Popova, T.G., Turell, M., Espina, V., Kehn-Hall K., Kidd, J., Narayanan, A., Liotta, L., Petricoin, E.F. 3rd , Kashanchi, F., Bailey, C. and Popov, S.G. 2010. Reverse-Phase Phosphoproteome Analysis of Signaling Pathways Induced by Rift Valley Fever Virus in Human Small Airway Epithelial Cells. PLoS ONE.  5(11):e13805