Monique Van Hoek, Ph.D., Associate Professor

Contact Information: 
Email: mvanhoek@gmu.edu
Phone: 703.993.4273
Fax: 703.993.7019

 

 

 

Biosketch:

Dr. Van Hoek received her bachelors degree in Biochemistry from the University of Victoria (Canada). She received her PhD from the University of Virginia, Department of Microbiology working in the Parsons-Weber-Parsons group. Dr. van Hoek then worked for Boehringer-Mannheim, which then became Roche Molecular Biochemical Division, for many years, developing and launching new biochemical products for life-science researchers.  She joined George Mason University in 2002.  Dr. van Hoek conducts her research in the School of Systems Biology and the National Center for Biodefense and Infectious Diseases with a focus on Francisella tularensis, Burkholderia pseudomallei,  and novel antimicrobials and host-pathogen interactions.  Dr. van Hoek currently teaches “BIOL 695/BIOS 704: Microbial Pathogenesis” graduate seminar and “BIOL 691: Introduction to Aerosol Biology.”

 

Research Interests:

Drug delivery and treatment for Francisella tularensis (tularemia), Burkholderia pseudomallei (melioidosis), other gram-negative and gram-positive human pathogens (Pseudomonas, Staphylococcus aureus (MRSA), Acinetobacter, Mycobacterium), Host-Pathogen Interactions (especially phosphorylation-based signal transduction), Development of novel antimicrobials and anti-biofilm compounds, Microbial physiology of Francisella, Burkholderia pseudomallei, Bacterial vaccines, Outer Membrane Vesicles, Proteomics, Bacterial biofilms and quorum sensing, exosomes.

 

Recent Selected Publications:

  1. Propst CN, Nwabueze AO, Kanev IL, Pepin RE, Gutting BW, Morozov VN, van Hoek ML. Nanoaerosols reduce required effective dose of liposomal levofloxacin against pulmonary murineFrancisella tularensis subsp. novicida infection. J Nanobiotechnology. 2016 Apr 18;14:29. [IF: 4.239] Publication PDF
  2. Juba ML, Russo PS, Devine M, Barksdale S, Rodriguez C, Vliet KA, Schnur JM, van Hoek ML, Bishop BM. Large Scale Discovery and De Novo-Assisted Sequencing of Cationic Antimicrobial Peptides (CAMPs) by Microparticle Capture and Electron-Transfer Dissociation (ETD) Mass Spectrometry. J Proteome Res. 2015 Oct 2;14(10):4282-95. [IF: 4.173] Publication PDF
  3. Dean SN, Chung MC, van Hoek ML. BurkholderiaDiffusible Signal Factor Signals to Francisella novicida To Disperse Biofilm and Increase Siderophore Production. Appl Environ Microbiol. 2015 Oct; 81(20):7057-66. [IF: 3.823] Publication PDF
  4. Dean SN, Walsh C, Goodman H, van Hoek ML. Analysis of mixed biofilm (Staphylococcus aureusand Pseudomonas aeruginosa) by laser ablation electrospray ionization mass spectrometry. Biofouling. 2015;31(2):151-61. [IF: 3.000] Publication PDF
  5. Blower RJ, Barksdale SM, van Hoek ML. Snake Cathelicidin NA-CATH and Smaller Helical Antimicrobial Peptides Are Effective againstBurkholderia thailandensis. PLoS Negl Trop Dis. 2015 Jul 21;9(7):e0003862. [IF: 3.948] Publication PDF
  6. Bishop BM, Juba ML, Devine MC, Barksdale SM, Rodriguez CA, Chung MC, Russo PS, Vliet KA, Schnur JM, van Hoek ML. Bioprospecting the American alligator (Alligator mississippiensis) host defense peptidome. PLoS One. 2015 Feb 11;10(2):e0117394. [IF: 3.057] Publication PDF
  7. Dean SN, van Hoek ML. Screen of FDA-approved drug library identifies maprotiline, an antibiofilm and antivirulence compound with QseC sensor-kinase dependent activity in Francisella novicida. Virulence. 2015;6(5):487-503. doi: 10.1080/21505594.2015.1046029. [IF: 5.418, Citations: 9] Publication PDF

 

Talks:

TEDxGeorgeMasonU talk: “Healed by a Crocodile: the Search for New Antibiotics”. April 6th 2013

 

Publications:

Full list of Monique van Hoek’s publications available at: http://www.ncbi.nlm.nih.gov/sites/myncbi/monique.van hoek.1/bibliography/40234026/public/?sort=date&direction=descending

  1. Barksdale SM, Hrifko EJ, Chung EM, van Hoek ML. Peptides from American alligator plasma are antimicrobial against multi-drug resistant bacterial pathogens including Acinetobacter baumannii. BMC Microbiol. 2016 Aug 19;16(1):189. [IF: 2.581]
  2. Kaushal A, Gupta K, Shah R, van Hoek ML. Antimicrobial activity of mosquito cecropin peptides against Dev Comp Immunol. 2016 May 26;63:171-180. [IF: 3.620]
  3. Propst CN, Pylypko SL, Blower RJ, Ahmad S, Mansoor M, van Hoek ML. Francisella philomiragia Infection and Lethality in Mammalian Tissue Culture Cell Models, Galleria mellonella, and BALB/c Mice. Front Microbiol. 2016 May 24;7:696. [IF: 4.165]
  4. Propst CN, Nwabueze AO, Kanev IL, Pepin RE, Gutting BW, Morozov VN, van Hoek ML. Nanoaerosols reduce required effective dose of liposomal levofloxacin against pulmonary murine Francisella tularensis subsp. novicida J Nanobiotechnology. 2016 Apr 18;14:29. [IF: 4.239]
  5. Kaushal A, Gupta K, van Hoek ML. Characterization of Cimex lectularius (bedbug) defensin peptide and its antimicrobial activity against human skin microflora. Biochem Biophys Res Commun. 2016 Feb 19;470(4):955-60. [IF: 2.371]
  6. Stephens MD, Hubble VB, Ernst RK, van Hoek ML, Melander RJ, Cavanagh J, Melander C. Potentiation of Francisella Resistance to Conventional Antibiotics through Small Molecule Adjuvants. Medchemcomm. 2016 Jan 1;7(1):128-131. [IF: 2.319]
  7. Juba ML, Russo PS, Devine M, Barksdale S, Rodriguez C, Vliet KA, Schnur JM, van Hoek ML, Bishop BM. Large Scale Discovery and De Novo-Assisted Sequencing of Cationic Antimicrobial Peptides (CAMPs) by Microparticle Capture and Electron-Transfer Dissociation (ETD) Mass Spectrometry. J Proteome Res. 2015 Oct 2;14(10):4282-95. [IF: 4.173]
  8. Dean SN, Chung MC, van Hoek ML. Burkholderia Diffusible Signal Factor Signals to Francisella novicida To Disperse Biofilm and Increase Siderophore Production. Appl Environ Microbiol. 2015 Oct; 81(20):7057-66. [IF: 3.823]
  9. Chung MC, Dean SN, van Hoek ML. Acyl carrier protein is a bacterial cytoplasmic target of cationic antimicrobial peptide LL-37. Biochem J. 2015 Sep 1;470(2):243-53. [IF: 3.562]
  10. Gupta K, Singh S, van Hoek ML. Short, Synthetic Cationic Peptides Have Antibacterial Activity against Mycobacterium smegmatis by Forming Pores in Membrane and Synergizing with Antibiotics. Antibiotics (Basel). 2015 Aug 24;4(3):358-78.
  11. Dean SN, Walsh C, Goodman H, van Hoek ML. Analysis of mixed biofilm (Staphylococcus aureus and Pseudomonas aeruginosa) by laser ablation electrospray ionization mass spectrometry. Biofouling. 2015;31(2):151-61. [IF: 3.000]
  12. Schwab A, Meyering SS, Lepene B, Iordanskiy S, van Hoek ML, Hakami RM, Kashanchi F. Extracellular vesicles from infected cells: potential for direct pathogenesis. Front Microbiol. 2015 Oct 20;6:1132. [IF: 4.165]
  13. Blower RJ, Barksdale SM, van Hoek ML. Snake Cathelicidin NA-CATH and Smaller Helical Antimicrobial Peptides Are Effective against Burkholderia thailandensis. PLoS Negl Trop Dis. 2015 Jul 21;9(7):e0003862. [IF: 3.948]
  14. Bishop BM, Juba ML, Devine MC, Barksdale SM, Rodriguez CA, Chung MC, Russo PS, Vliet KA, Schnur JM, van Hoek ML. Bioprospecting the American alligator (Alligator mississippiensis) host defense peptidome. PLoS One. 2015 Feb 11;10(2):e0117394. [IF: 3.057]
  15. Ulrey RK, Barksdale SM, Zhou W, van Hoek ML. Cranberry proanthocyanidins have anti-biofilm properties against Pseudomonas aeruginosa. BMC Complement Altern Med. 2014 Dec 16;14:499. doi: 10.1186/1472-6882-14-499. [IF: 2.020, Citations: 8]
  16. Dean SN, van Hoek ML. Screen of FDA-approved drug library identifies maprotiline, an antibiofilm and antivirulence compound with QseC sensor-kinase dependent activity in Francisella novicida. Virulence. 2015;6(5):487-503. doi: 10.1080/21505594.2015.1046029. [IF: 5.418, Citations: 9]
  17. Fleming A, Sampey G, Chung MC, Bailey C, van Hoek ML, Kashanchi F, Hakami RM. The carrying pigeons of the cell: exosomes and their role in infectious diseases caused by human pathogens. Pathog Dis. 2014 Jul;71(2):109-20. doi: 10.1111/2049-632X.12135. [IF: 2.403, Citations: 17]
  18. van Hoek ML. Antimicrobial peptides in reptiles. Pharmaceuticals (Basel). 2014 Jun 10;7(6):723-53. doi: 10.3390/ph7060723. [Citations: 17]
  19. Chung MC, Dean S, Marakasova ES, Nwabueze AO, van Hoek ML. Chitinases are negative regulators of Francisella novicida PLoS One. 2014 Mar 24;9(3):e93119. doi: 10.1371/journal.pone.0093119. eCollection 2014. [IF: 2.234, Citations: 4]
  20. Morozov, VN, Kanev, IL, Mikheev, AY, Shlyapinkova, EA, Shlyapnikov, YM, Nikitin, MP, Nitikin, PI, Nwabueze, AO, van Hoek, ML. Generation and delivery of nanoaerosols from biological and biologically active substances. Journal of Aerosol Science 69: 48-61. March 2014. doi: 10.1016/j.jaerosci.2013.12.003. [IF: 2.236, Citations: 8]
  21. van Hoek ML. Biofilms: an advancement in our understanding of Francisella Virulence. 2013 Nov 15;4(8):833-46. doi: 10.4161/viru.27023. [IF: 3.319, Citations: 12]
  22. Marakasova ES, Akhmatova NK, Amaya M, Eisenhaber B, Eisenhaber F, van Hoek ML, Baranova AV. [Prenylation: from bacteria to eukaryotes]. Mol Biol (Mosk). 2013 Sep-Oct;47(5):717-30. Review. Russian.
  23. Duplantier, A. & van Hoek, M.L. “The human cathelicidin antimicrobial peptide LL-37 as a potential treatment for polymicrobial infected wounds.” Frontiers in Immunology, 2013 Jul 3;4:143. [IF: 5.695, Citations: 44]

 

JSTO-In the News (CBS Input – December 2012)

DTRA Funded Effort Studies Anti-infective Properties of Reptile Serum Seven months ago, DTRA initiated a research effort to take advantage of the anti-infective properties of reptile serum. The concept is to identify and use constitutive parts of serum that enables animals to fight infection, notably cationic antimicrobial peptides. These peptides will be isolated using a novel, nanoparticle-based approach. The foundation for this DTRA-funded work is research performed at George Mason University (GMU) in the laboratories of Dr. Monique van Hoek (National Center for Biodefense and Infectious Diseases) and Dr. Barney Bishop (Department of Chemistry) that demonstrated anti-microbial and anti-biofilm properties of these CAMPs. Recently, their published work has been recognized by the respective journals as being among the highest viewed articles.  For example, their paper in Frontiers in Microbiology has received 1391 views [1]. The companion paper in BMC Microbiology was “Highly Accessed” with 5647 views so far [2], and a second companion paper in BBRC received a favorable score in a Faculty of 1000 review [3,4]. All of the researchers and students involved are very excited to be working on this project. The principal investigator on the project HDTRA1-12-C-0039 “Translational Peptides for Personal Protection” is Dr. Joel Schnur. (POC Al Graziano, 767-3360) 1. Dean, S. N., Bishop, B. M., & Van Hoek, M. L. (2011). Susceptibility of Pseudomonas aeruginosa biofilm to alpha-helical peptides: D-enantiomer of LL-37. Frontiers in Microbiology, 2. 2. Dean, S. N., Bishop, B. M., & van Hoek, M. L. (2011). Natural and synthetic cathelicidin peptides with anti-microbial and anti-biofilm activity against Staphylococcus aureus. BMC Microbiology, 11(1), 114. 3. Amer, L. S., Bishop, B. M., & van Hoek, M. L. (2010). Antimicrobial and antibiofilm activity of cathelicidins and short, synthetic peptides against Francisella. Biochemical and Biophysical Research Communications, 396(2), 246-251. 4. http://f1000.com/prime/6167956

TEDxGeorgeMasonU talk: “Healed by a Crocodile: the Search for New Antibiotics”. April 6th 2013

 

Awards:

  1. 2013 OSCAR Mentoring Excellence Award
    Website: http://oscar.gmu.edu/fac-staff/2013-mentoring-award-winners.cfm
  2. College of Science Teaching Award Apr 2012
    Awarding Authority: George Mason University College of Science Website: http://cos.gmu.edu/news/spring-12/college-science-publication-teaching-awards
    The Teaching Award recognizes COS faculty members at George Mason University who are outstanding teachers or mentors or who have made major contributions to COS educational activities during the 2010–2011 academic year.
  3. J. Shelton Horsley Research Award  01 May 2009
    Awarding Authority: Virginia Academy of Science Website: http://www.vacadsci.org/funding2010/Horsley.pdf
    The J. Shelton Horsley Research Award is the highest honor bestowed by the Virginia Academy of Science for original research. The presentation of a certificate and a monetary award are a highlight of the Annual Meeting.

 

Latest News: 

http://newsdesk.gmu.edu/2014/09/bugged-mason-researchers-try-solve-bed-bug-mystery-help-save-human-lives/

http://4va.gmu.edu/innovationgrants/

 

Expert Commentary:

http://www.rsc.org/chemistryworld/2014/03/molecular-drill-bits-amp-peptides-attack-tuberculosis-bacteria

Chemistry World: Could wasp venom peptide keep catheters sterile? 14 August 2013