DTRA Funded Effort Studies Anti-infective Properties of Reptile Serum Seven months ago, DTRA initiated a research effort to take advantage of the anti-infective properties of reptile serum. The concept is to identify and use constitutive parts of serum that enables animals to fight infection, notably cationic antimicrobial peptides. These peptides will be isolated using a […]
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Dr. Kehn-Hall and Dr. Narayanan (Co-PI, GMU) have received a five year grant from DTRA entitled “Molecular Pathogenesis of Select Agent Viruses and their Attenuated Vaccine Derivatives”. This project is in collaboration with Dr. Connie Schmaljohn’s laboratory at USAMRIID. The objectives of this grant are (1) to identify significant differences at the host response level […]
Dr. Kehn-Hall and Dr. Jonathan Jacobs (Co-PI, MRIGlobal) have received a three year grant from DTRA entitled “Interactions of Alphaviruses with the Host MicroRNA Processing Machinery”. This project also involves a collaboration with Dr. Jonathan Dinman’s laboratory at University of Maryland. The objective of this grant is to determine the importance and mechanism of specific […]
Dr. Kehn-Hall and Dr. Narayanan (Co-PI, GMU) have received a three year NIH R15 grant entitled “Induction of DNA Damage Signaling Cascade upon RVFV Infection”. This grant is aimed at determining the mechanism by which RVFV NSs induces DNA damage signaling and how this signaling aids in viral replication in vitro and in vivo.
Dr. Kehn-Hall has received a subcontract from Ceres Nanosciences to facilitate work on a DARPA project
Dr. Kehn-Hall has received a subcontract from Ceres Nanosciences to facilitate work on a DARPA project entitled “Universal Nanotrap-enabled Biofluid Sample Preparation and Storage Toolset”. This is a two year grant that is focused on testing whole virus capture and preservation with NanoTrap particles both in liquid and on filter paper for RVFV, Influenza, and […]
Dr. Kehn-Hall and Dr. Carpenter have received a contract from Unither Virology entitled “Animal Modeling Development and Therapeutic Testing”. This contract will focus on the development of an aerosol exposure mouse model of Venezuelan Equine Encephalitis Virus.
The George Mason Biomedical Research Laboratory received the Certificate of Registration from the Centers for Disease Control prevention on February 27, 2012. This certification approves the Biomedical Research Laboratory to work with Centers for Disease Control (CDC) and Animal and Plant Health Inspection Service (APHIS) select agents.
The latest findings from the Popov Lab: In the recent article, Anthrolysin O and fermentation products mediate the toxicity of Bacillus anthracis to lung epithelial cells under microaerobic conditions (FEMS Immunol Med Microbiol. 2011 Feb;61(1):15-27), Popova T.G., Millis B., Chung M.C., Bailey C., and Popov S.G. reported on the discovery of a new, previously […]
Some for the major fundings grants from Kashanchi lab: An NIH R01 grant on Tat peptide derivatives (mimetics) inhibitors that could potentially inhibit virus replication both in cell culture and humanized animal models. The understanding of how HIV-1 Tat manipulates the transcription machinery will aid in designing better Tat inhibitors of mimetic nature. An NIH […]
The links below report the latest research from the our recent research discovery in the Wu laboratory: http://www.sciencedaily.com/releases/2011/08/110824131850.htm http://news.bioscholar.com/2011/08/how-hiv-infects-healthy-t-cells-and-leads-to-the-development-of-aids.html http://www.connect2mason.com/content/mason-biology-professor-leads-research-team-hiv-breakthrough http://news.gmu.edu/articles/4972